| Description | RMC-3943 is a highly potent allosteric inhibitor of full-length SHP2, as demonstrated by its remarkable activity in a biochemical assay, with an IC50 value of 2.19 nM. |
| In vitro | RMC-3943 inhibits pERK in PC9 cells, with an IC 50 of 35.5 nM[1]. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1]. Cell Viability Assay Cell Line: SK-MEL-113 cells[1]. Concentration: 0-10 μM. Incubation Time: 7 days. Result: Inhibited cell proliferation. |
| molecular weight | 425.38 |
| Molecular formula | C18H22Cl2N6S |
| CAS | 1801764-60-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug. |