| Description | Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome. |
| In vitro | 与其他抗生素相比,Ribostamycin（400 mg/kg/day）造成的耳毒性最低,其在豚鼠内耳液中药物浓度较低.Ribostamycin对豚鼠耳蜗及前庭器官的耳毒性最低. |
| In vivo | Ribostamycin能够有效抑制耐庆大霉素的肺炎杆菌体内的氨基糖苷类修饰酶。Ribostamycin不抑制蛋白质二硫键异构酶（PDI）活性,但会其分子伴侣活性,Ribostamycin 与PDI以100：1的摩尔比可使其分子伴侣活性几乎完全受到抑制。Ribostamycin与免疫原PDI结合的KD为0.319 mM。Ribostamycin对人伯氏疏螺旋体菌群也有抗菌活性（MIC：18.7 mg/L）。 Ribostamycin（16 mcg/mL）对P. stagnora菌株、P. zopfii 菌株和P. wickerhamii菌株的抑制效果分别为100％、100％和95%。 |
| Synonyms | Vistamycin sulfate, 硫酸核糖霉素 |
| molecular weight | 552.55 |
| Molecular formula | C17H34N4O10·H2SO4 |
| CAS | 53797-35-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Insoluble H2O: 10 mM |
| References | 1. Horibe T, et al. Biochem Biophys Res Commun, 2001, 289(5), 967-972. 2. Hunfeld KP, et al. Int J Antimicrob Agents, 2001, 17(3), 203-208. 3. Casal M, et al. Mycopathologia, 1983, 83(1), 21-23. 4. Kitasato I, et al. Chemotherapy, 1990, 36(2), 155-168. |