| Description | Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50: 0.3 μM). |
| In vitro | Ribocil是一种高度特异性的合成活性模拟物，模仿FMN，与天然配体竞争，以抑制FMN核糖开关介导的ribB表达，并抑制细菌生长。Ribocil-B相比于Ribocil-A显示出更优越的微生物学活性（最小抑制浓度（MIC）= 1 μg/ml对比MIC ≥ 64 μg/ml）、抑制核黄素合成（IC50 = 0.13 μM对比IC50 > 26 μM）以及与大肠杆菌FMN aptamer的结合亲和力（Kd = 6.6 nM对比Kd ≥ 10,000 nM）[1]。 |
| molecular weight | 382.48 |
| Molecular formula | C19H22N6OS |
| CAS | 1381289-58-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 24.8 mg/mL (64.84 mM) |
| References | 1. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7. |