| Description | RH 421 is an amphiphilic styryl dye. |
| Synonyms | RH-421, RH421 |
| molecular weight | 498.72 |
| Molecular formula | C29H42N2O3S |
| CAS | 107610-19-5 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Mikhaĭlova EV, Efimova SS, Ostroumova OS. [The effects of RH 421 on the activity of amphotericin B in cell and model membranes]. Tsitologiia. 2013;55(2):136-9. Russian. PubMed PMID: 23718076. 2. Ostroumova OS, Efimova SS, Mikhailova EV, Schagina LV. The interaction of dipole modifiers with amphotericin-ergosterol complexes. Effects of phospholipid and sphingolipid membrane composition. Eur Biophys J. 2014 May;43(4-5):207-15. doi: 10.1007/s00249-014-0946-0. Epub 2014 Feb 23. PubMed PMID: 24563224. 3. Apetrei A, Mereuta L, Luchian T. The RH 421 styryl dye induced, pore model-dependent modulation of antimicrobial peptides activity in reconstituted planar membranes. Biochim Biophys Acta. 2009 Aug;1790(8):809-16. doi: 10.1016/j.bbagen.2009.04.002. Epub 2009 Apr 9. PubMed PMID: 19362116. 4. Chulkov EG, Schagina LV, Ostroumova OS. Membrane dipole modifiers modulate single-length nystatin channels via reducing elastic stress in the vicinity of the lipid mouth of a pore. Biochim Biophys Acta. 2015 Jan;1848(1 Pt A):192-9. doi: 10.1016/j.bbamem.2014.09.004. Epub 2014 Sep 16. PubMed PMID: 25223717. |