| Description | RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) acetate is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM. |
| In vitro | RFRP-3(human) acetate 有效抑制了forskolin诱导的cAMP产生，其IC50为0.7 nM。Scatchard图分析显示，标记了125I的hRFRP-3在表达大鼠OT7T022的CHO细胞膜分数中，具有一个高亲和力的单一类绑定位点，其Kd值为0.19 nM，Bmax值为1.3 pM。RFRP-3(human) acetate 特异性激活了转染了新型孤儿7TMR，OT7T022的细胞，它作为具有高亲和力的特异性配体与OT7T022结合(Kd= 0.19 nM)[1]。 |
| molecular weight | 1029.19 |
| Molecular formula | C47H76N14O12 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. IJ Clarke, IP Sari, Y Qi,etc. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion.[J]. Endocrinology, 2008(11):5811. |
RFRP3(human) acetate(311309-27-0 free base)
CAS No.:
RFRP-3(human) acetate, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+
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