| Description | Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10. |
| molecular weight | 222.19 |
| Molecular formula | C11H10O5 |
| CAS | 26246-41-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Lim DS, Kwak YS, Lee KH, Ko SH, Yoon WH, Lee WY, Kim CH. Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Chemotherapy. 2003 Sep;49(5):257-63. PubMed PMID: 14504438. 2. Lim DS, Kwak YS, Kim JH, Ko SH, Yoon WH, Kim CH. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53. PubMed PMID: 12815208. 3. Ryoo IJ, Xu GH, Kim YH, Choo SJ, Ahn JS, Bae K, Yoo ID. Reticulone, a novel free radical scavenger produced by Aspergillus sp. J Microbiol Biotechnol. 2009 Dec;19(12):1573-5. PubMed PMID: 20075621. 4. Mitscher LA, Andres WW, McCrae W. Reticulol, a new metabolic isocoumarin. Experientia. 1964 May 15;20(5):258-9. PubMed PMID: 5856305. |