| Description | Retene (NSC-26317) is widely present in recent and ancient sediments, and compounds can be extracted from fir forest soils, humic coals, terrestrial petroleum hydrocarbon source rocks, and deep-sea sediments.Retene is produced by dehydrogenation of pine acids during petrogenesis. |
| In vitro | 在实验室条件下，白鱼幼体先暴露于retene（10、32和100μg/L）并设置相应对照组，然后在半静态测试中使用两种不同剂量的UV-B（CIE加权2.8或5.4千焦/平方米/天）或仅可见光照射3小时（连续两天）。retene的光诱导急性LC(50)为13.3μg/L。接受retene处理的鱼展现出行为刺激和低氧血症的迹象，并在UV光照射期间和之后受到影响。在同时暴露于retene和UV-B的幼体中检测到严重的皮肤损伤。即便在最低的retene浓度下，同时进行化学处理和UV-B处理也会显著增加粘液细胞的数量。我们认为组织反应是对UV诱导的retene毒性的保护反应。此外，关于肝脏实质，与UV-B同时暴露于retene的鱼出现了病变，显示出肝毒性。在UV-B和溶剂对照组（DMSO）中也能看到晒伤的结构迹象。[1] |
| In vivo | Retene (7-isopropyl-1-methylphenanthrene)是一种天然形成的多环芳烃（PAH），能导致鱼类幼体畸形并诱导细胞色素P450（CYP1A）酶的活化。Retene在受到来自纸浆厂废水中树脂酸污染的表层沉积物中以高浓度（≤3300 microg/g dry wt）存在。在芬兰赛马湖附近，一个排放到湖中的漂白牙硬浆纸厂周围采集的工业污染沉积物显著诱导了鳟鱼肝脏CYP1A活性的增加，这表明积累了芳烃受体（AhR）活性配体。用retene或苯并[k]荧蒽处理沉积物暴露于鱼类的实验支持了这一结论。 |
| Target activity | Whitefish larvae:13.3 microg/L(LC50) |
| Synonyms | NSC 26317, NSC-26317, NSC26317 |
| molecular weight | 234.34 |
| Molecular formula | C18H18 |
| CAS | 483-65-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 18.33 mg/mL (78.23 mM) |
| References | 1. Häkkinen J, et al. Histopathological responses of newly hatched larvae of whitefish (Coregonus lavaretus s.l.) to UV-B induced toxicity of retene. Aquat Toxicol. 2003;63(2):159-171. 2. Oikari A, et al. Bioavailability to juvenile rainbow trout (Oncorynchus mykiss) of retene and other mixed-function oxygenase-active compounds from sediments. Environ Toxicol Chem. 2002;21(1):121-128. 3. Maria VL, et al. Anguilla anguilla L. liver EROD induction and genotoxic responses after retene exposure. Ecotoxicol Environ Saf. 2005;61(2):230-238. 4. Geier MC, et al. Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol. 2018;41(18)30121-30122. 5. Sun H, et al. Direct determination of surfactant effects on the uptake of gaseous parent and alkylated PAHs by crop leaf surfaces. Ecotoxicol Environ Saf. 2018;154:206-213. 6. Bandowe BAM, et al. A 150-year record of polycyclic aromatic compound (PAC) deposition from high Andean Cajas National Park, southern Ecuador. Sci Total Environ. 2018;621:1652-1663. 7. De Oliveira Alves N, et al. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Sci Rep. 2017;7(1):10937. |