| Description | RET-IN-23 (compound 17) is a potent, orally active inhibitor of RET, displaying IC50 values of 1.32 nM for RET-WT, 2.50 nM for RET-CCDC6, 6.54 nM for RET-V804L, 1.03 nM for RET-V804M, and 1.47 nM for RET-M918T. The compound demonstrates significant anti-tumor activity [1]. |
| In vivo | RET-IN-23（5 mg/kg；口服）在小鼠模型中表现出了抗肿瘤效果[1]。 |
| molecular weight | 537.59 |
| Molecular formula | C28H28FN11 |
| CAS | 2479961-46-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |