| Description | ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy. |
| Synonyms | NNC-05-1869, NNC 05-1869, NNC-051869, ReN 1869 |
| molecular weight | 361.48 |
| Molecular formula | C24H27NO2 |
| CAS | 170149-99-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Schaffler K, Seibel K, Thomsen M, Edwards M. Effect of the new H1-antagonist ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser. Arzneimittelforschung. 2004;54(3):187-91. PubMed PMID: 15112866. 2. Suzuki R, Edwards M, Dickenson AH. ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperi dine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy. J Pharmacol Exp Ther. 2004 Jun;309(3):1230-8. PubMed PMID: 14988422. 3. Skrumsager BK, Ingwersen SH, Gerrits M. Safety and pharmacokinetics of ReN1869: a first human dose study in healthy subjects after single-dose administration. J Clin Pharmacol. 2003 Jan;43(1):66-73. PubMed PMID: 12520630. 4. Olsen UB, Eltorp CT, Ingvardsen BK, Jørgensen TK, Lundbaek JA, Thomsen C, Hansen AJ. ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57. PubMed PMID: 11790377. |