| Description | RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation[1]. |
| In vitro | RBPJ Inhibitor-1 (RIN1)（2 μM）引起的基因表达变化更类似于RBPJ的siRNA沉默，而不是在NOTCH本身水平的抑制。与NOTCH信号的破坏一致，RIN1（0.6 μM）抑制了血液癌细胞系的增殖，并促进了C2C12肌母细胞向骨骼肌的分化。因此，RIN1在其抑制和激活上下文中抑制RBPJ，并可用于化学生物学和治疗应用。[1] |
| Synonyms | RIN1 |
| molecular weight | 311.31 |
| Molecular formula | C17H14FN3O2 |
| CAS | 2682114-39-0 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 225.0 mg/mL (722.8 mM), Sonication is recommended. |
| References | 1. Hurtado C, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019;9(1):10811. 2. Fujioka M, et al. Cloning of a novel splicing variant of RIN1 and its expression in gastric and colon cancer. Oncol Res. 2009;17(11-12):593-599. 3. Milstein M, et al. RIN1 is a breast tumor suppressor gene. Cancer Res. 2007;67(24):11510-11516. |