| Description | Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic with activity against gram-positive bacteria. It is existed in the Actinoplanes spp. |
| In vitro | Ramoplanin blocks peptidoglycan synthesis via lipid II, then exerts bactericidal activity against gram-positive aerobic and anaerobic bacteria [1]. |
| In vivo | During treatment, Ramoplanin (100, 500 μg/ml; p.o.; for 8 days) suppresses vancomycin-resistant Enterococcus (VRE) to undetectable level [1]. |
| molecular weight | N/A |
| CAS | 76168-82-6 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Stiefel U, et al. Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice. Antimicrob Agents Chemother. 2004 Jun;48(6):2144-8. 2. Cheng M, et al. Ramoplanin at bactericidal concentrations induces bacterial membrane depolarization in Staphylococcus aureus. Antimicrob Agents Chemother. 2014 Nov;58(11):6819-27. |