| Description | (Rac)-BMS-816336 (Compound 6n), a racemate of BMS-816336, is a potent inhibitor of the human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme, demonstrating IC50 values of 10 nM and 68 nM, respectively. It exhibits good metabolic stability [1]. |
| In vivo | (Rac)-BMS-816336 (compound 6n) has good metabolic stability with the remaining rates in human, mouse and rats of 88%,82% and 72%, respectively [1]. |
| Target activity | 11β-HSD1 (human):10 nM , 11β-HSD1 (mouse):68 nM |
| molecular weight | 341.44 |
| Molecular formula | C21H27NO3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948. |