| Description | R59949 is used as a Diacylglycerol kinase (DGK) inhibitor. |
| Synonyms | R-59949, R 59949 |
| molecular weight | 489.58 |
| Molecular formula | C28H25F2N3OS |
| CAS | 120166-69-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (122.55 mM) |
| References | 1. Yang L, Xu Y, Li W, Yang B, Yu S, Zhou H, Yang C, Xu F, Wang J, Gao Y, Huang Y, Lu L, Liang X. Diacylglycerol kinase (DGK) inhibitor II (R59949) could suppress retinal neovascularization and protect retinal astrocytes in an oxygen-induced retinopathy model. J Mol Neurosci. 2015 May;56(1):78-88. doi: 10.1007/s12031-014-0469-2. Epub 2014 Dec 2. PubMed PMID: 25451596. 2. Tolan D, Conway AM, Pyne NJ, Pyne S. Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle. Am J Physiol. 1997 Sep;273(3 Pt 1):C928-36. PubMed PMID: 9316414. 3. Nakamura T, Kamishikiryo J, Morita T. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II. Pharmacol Rep. 2016 Jun;68(3):649-53. doi: 10.1016/j.pharep.2016.02.001. Epub 2016 Feb 22. PubMed PMID: 27031052. 4. Torres-Ayuso P, Daza-Martín M, Martín-Pérez J, Ávila-Flores A, Mérida I. Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src. Oncotarget. 2014 Oct 30;5(20):9710-26. PubMed PMID: 25339152; PubMed Central PMCID: PMC4259432. |
| Citations | 1. Wu D, Wang J, Chang Y, et al.Rutaecarpin reduces lipids by DGKθ‐dependent activation of PPARα.Obesity.2022, 30(12): 2424-2439. |