| Description | (R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active inhibitor of neutral metalloendopeptidase (NEP), with antihypertensive effect. |
| In vitro | NEP is a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro[1]. |
| molecular weight | 411.58 |
| Molecular formula | C20H29NO4S2 |
| CAS | 156792-25-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Neustadt BR, et al. Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem. 1994 Jul 22;37(15):2461-76. 2. Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. |