| Description | (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ). |
| Target activity | mGlu5:168 nM (EC50) |
| molecular weight | 369.36 |
| Molecular formula | C20H17F2N3O2 |
| CAS | 851881-59-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 95 mg/mL (257.20 mM) |
| References | 1. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-4727ChemMedChem. 2009 Apr;4(4):505-11. |