| Description | R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system. |
| In vitro | R-1479通过剂量依赖的方式抑制HCV RNA复制，并减少增殖的复制子细胞内Renillaluciferase活性[1]。此外，R-1479抑制由NS5B介导的RNA合成，其IC50值为320 nM，同时也针对HCV编码的RNA聚合酶[2]。 |
| Target activity | HCV replication:1.28 μM |
| Synonyms | 4'-Azidocytidine |
| molecular weight | 284.23 |
| Molecular formula | C9H12N6O5 |
| CAS | 478182-28-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (316.6 mM), Sonication is recommended. |
| References | 1. Klumpp K, et al. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9. 2. Smith DB, et al. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6. 3. Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450. |