| Description | Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes. |
| In vitro | Quinine是一种生物碱类抗疟疾化合物，其对泰国60株P. falciparum分离株的最小抑制浓度(MIC)值介于10至500 nM之间。它通过抑制纯化的滋养体中的血锌生成，从而增加自由血红素的含量，其作用机理与氯喹[1]相似。 |
| In vivo | 在小鼠体内，quinine可降低血液中的P. berghei寄生虫负荷，其最小有效剂量（MED）为150 mg/kg [2]。 |
| Target activity | P. falciparum (60 Thai isolates):10 to 500 nM (MIC) |
| Synonyms | 奎宁树 |
| molecular weight | 818.97 |
| Molecular formula | C40H58N4O12S |
| CAS | 6119-70-6 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 8.19 mg/mL (10 mM) |
| References | 1. Thaithong S, et al. Susceptibility of Plasmodium falciparum to five drugs: an in vitro study of isolates mainly from Thailand. Trans R Soc Trop Med Hyg. 1983;77(2):228-31. 2. THURSTON JP. The action of antimalarial drugs in mice infected with Plasmodium berghei. Br J Pharmacol Chemother. 1950 Sep;5(3):409-16. |