| Description | Pyriproxyfen (S-31183) is an insecticide that acts as a biomimetic of juvenile hormone. |
| In vivo | 斑马鱼成年雄性暴露于0.001、0.01和0.1μg/mL的Pyriproxyfen16小时。其脑组织的线粒体呼吸作用进行了评估。通过H2DCF-DA和MitoSOX估计ROS（活性氧）生成。采用Calcium Green 5 N监测钙传输。利用DAF-FM-DA估计NO（一氧化氮）合成活性。脑乙酰胆碱酯酶在体IC20为0.30μmol/LPyriproxyfen，IC50为92.5μmol/L，对zbAChE（斑马鱼乙酰胆碱酯酶）活性的抑制效应呈现竞争性。昆虫剂暴露后，复合物I/II的呼吸控制显著下降。MitoSOX测试显示O2^-（超氧阴离子）生成有Pyriproxyfen剂量依赖效应。在0.1μg/mLPyriproxyfen的浓度下，脑组织钙吸收能力损失了50%。钙释放在较低Pyriproxyfen暴露量下显示出明显的线粒体功能受损[1]。 |
| Target activity | AChE:92.5 μmol/L(Zebrafish brain) |
| Synonyms | S-31183, 吡丙醚 |
| molecular weight | 321.37 |
| Molecular formula | C20H19NO3 |
| CAS | 95737-68-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (155.58 mM) |