| Description | pyridoxal isonicotinoyl hydrazone (PIH) is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows high iron chelation efficacy both in vitro and in vivo. |
| In vitro | 在59Fe标记的网织红细胞与tris-羟基胺基脱铁素(5 mmol/L)重新孵育60分钟后，细胞内的59Fe有3.5%被释放。然而，pyridoxal isonicotinoyl hydrazone（PIH）在50倍较低浓度(0.1 mmol/L)下，释放了38.6%的细胞内59Fe [1]。在初级人类肝细胞和人类肝细胞癌细胞系HepG2/C3A中，PIH处理降低了Fech蛋白水平，但Fech mRNA水平不变；并且在异烟肼处理后可以检测到PIH，当外源性维生素B6类似物共同给药时，PIH水平进一步增加[2]。 |
| In vivo | 小鼠经腹腔注射PIH（每天每只25克小鼠5毫克）连续6天后，其肝脏、脾脏及肾脏内的59Fe水平降低，但血液中的未见明显变化。口服PIH后，小鼠粪便中的Fe排泄量增加了八倍，同时可能也增加了一定的尿液Fe排泄量[1]。 |
| Synonyms | 吡哆醛异烟酰肼, PIH |
| molecular weight | 286.29 |
| Molecular formula | C14H14N4O3 |
| CAS | 737-86-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 28.63 mg/mL (100 mM) |
| References | 1. 1. Richardson DR, et al. Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. J Lab Clin Med. 1998 Apr;131(4):306-15. 2. Brewer CT, et al. The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. Toxicol Sci. 2019 Mar 1;168(1):209-224. |
pyridoxal isonicotinoyl hydrazone
CAS No.: 737-86-0
pyridoxal isonicotinoyl hydrazone (PIH) is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows hig
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