| Description | Psychosine (Galactosylsphingosine) is a PKC inhibitor, a substrate for the enzyme galactosylceramide cerebrosidase (GALC), and a potential biomarker of Krabbe's disease.Psychosine is highly cytotoxic and induces cell death in a variety of cells. |
| In vitro | 在 Oligodendrocyte 细胞系 M03.13 中，Psychosine（10、20和 40μM；24 小时）至少部分通过凋亡诱导细胞死亡[2]。 |
| Synonyms | Sphingosine galactoside, Galactosylsphingosine, Galactosylsphingosine (d18:1) |
| molecular weight | 461.63 |
| Molecular formula | C24H47NO7 |
| CAS | 2238-90-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 1 mg/mL (2.17 mM), Sonication is recommended. DMSO: 1 mg/mL (2.17 mM), Sonication is recommended. |
| References | 1. M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121(3):271-278. 2. Jacqueline A Hawkins-Salsbury,et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54(12):3303-11. 3. Belleri M,et al. β-Galactosylceramidase in cancer: more than a psychosine scavenger. Oncoscience. 2022 Mar 23;9:11-12. 4. Spassieva S,et al. Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease. J Neurosci Res. 2016 Nov;94(11):974-81. |