| Description | Protogracillin is a steroidal saponin isolated from Dioscorea zingiberensisWright (DZW). The steroidal saponin obtained from DZW rhizomes has antithrombotic properties and also consists of the potential to reduce the risk of cardiovascular disease. |
| In vitro | Paris polyphylla J.E. Smith 在印度和中国的传统医学体系中广泛应用，主要因其抗癌性质。P. polyphylla 的国内外需求不断增加，而大部分供应来自野生。非法和非科学的开发利用加上栖息地破坏导致该草本植物自然种群减少，因此这种物种被归类为脆弱类。恢复和保护这种潜力草本植物的自然种群是先决条件。方法与结果：本文旨在提供P. polyphylla 的化学和生物学前景概览。从P. polyphylla 中分离出次级代谢产物，如daucosterol, polyphyllin D, β-ecdysterone, Paris saponins I, II, V, VI, VII, H, dioscin, oligosaccharides, heptasaccharide, octasaccharide, trigofoenoside A, Protogracillin, Paris yunnanosides G-J, padelaoside B, pinnatasterone, formosanin C 以及20-hydroxyecdyson saponins等。也报告了多种生物活性，如抗癌、抗肿瘤、细胞毒、驱虫、抗微生物、抗血管生成、免疫刺激、收缩和止血。结论：因此，本综述将助于研究者和科学家进行进一步研究。 |
| Synonyms | 原纤细薯蓣皂甙 |
| molecular weight | 1065.2 |
| Molecular formula | C51H84O23 |
| CAS | 54848-30-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 30 mg/mL (28.16 mM) |
| References | 1. Paris polyphylla: chemical and biological prospectives. Anticancer Agents Med Chem. 2014;14(6):833-9. 2. Li H, et al. Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright. Fitoterapia. 2010 Dec;81(8):1147-56. |