| Description | Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor. |
| Synonyms | 5-(2-methylpiperazine-1-sulfonyl)isoquinoline, 蛋白激酶抑制剂H-7, 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine |
| molecular weight | 291.37 |
| Molecular formula | C14H17N3O2S |
| CAS | 84477-87-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (308.9 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41. |