| Description | PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of cancer cells.CAS 번호5017-88-83-4 |
| In vitro | SGK3-PROTAC1 （0.3 μM） 在 2 小时内诱导内源性 SGK3 降解 50%，在 8 小时内观察到最大降解 80%，伴有 SGK3 底物 NDRG1 磷酸化丧失[1]。 |
| Synonyms | SGK3-PROTAC1 |
| molecular weight | 1157.38 |
| Molecular formula | C57H73FN10O11S2 |
| CAS | 2381320-35-8 |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (69.12 mM), Sonication is recommended. |
| References | 1. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. |