| Description | PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as part of its structure. It effectively inhibits cell death in a TSZ-induced model of necroptosis. |
| molecular weight | 948.05 |
| Molecular formula | C46H55F2N9O9S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |