| Description | Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP. |
| Synonyms | 前列地尔, PGE1, 列腺素E1, Alprostadil |
| molecular weight | 354.48 |
| Molecular formula | C20H34O5 |
| CAS | 745-65-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 17.7 mg/mL (50 mM) |
| References | 1. Dijkstra BG, et al. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2622-6. |
| Citations | 1. Zhang T, Liu L, Huang X, et al.Application of microfluidic chip technology to study the inhibitory effect of tetramethylpyrazine on platelet aggregation, activation, and phosphatidylserine exposure mediated by pathological high shear rate.Blood Coagulation & Fibrinolysis.2023, 34(1): 47-60. 2. Zhang T, Liu L, Huang X, et al.The rapid change of shear rate gradient is beneficial to platelet activation.Platelets.2024, 35(1): 2288679. |