| Description | Prosaikogenin F ((2R,3R,4S,5R,6R)-2-{[(1S,2R,4S,5R,8R,9S,10R,13S,14R,17S,18R)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,1?.0?,1?.0?,1?.0?,13]tetracos-15-en-10-yl]oxy}-6-methyloxane-3,4,5-triol) is a natural product with anticancer and hemolytic properties [1]. |
| In vitro | Prosaikogenin F 在不同浓度下对A549细胞增殖的抑制作用显着，当浓度分别为20、40及60 μg/mL时，抑制率分别达到了40.53%、92.62%及93.07% [1]。同时，prosaikogenin F 对HCT 116癌细胞的IC50值为14.21 μM [2]。 |
| In vivo | 经腹腔给药Saikosaponin A及其肠道代谢产物Prosaikogenin F，在0.1 mmol/kg的剂量下可诱导皮质酮分泌，并在0.4 mmol/kg的剂量下可使皮质酮分泌达到最大增幅[3]。 |
| Synonyms | 前柴胡皂苷F |
| molecular weight | 618.84 |
| Molecular formula | C36H58O8 |
| CAS | 99365-20-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Lu Shi, et al. A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San. Curr Med Sci. 2020 Feb;40(1):138-144. 2. Ji-Eun Lee, et al. Production of Prosaikogenin F, Prosaikogenin G, Saikogenin F and Saikogenin G by the Recombinant Enzymatic Hydrolysis of Saikosaponin and their Anti-Cancer Effect. Molecules. 2022 May; 27(10): 3255. 3. M Nose, et al. Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract. Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2736-40. |