Prolyl-4-hydroxylase Inhibitor 11 Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Prolyl-4-hydroxylase Inhibitor 11, a novel proline 4-hydroxylase inhibitor, shows protective effects against oxidative stress and Cu(II) toxicity in Chlorella vulgaris.
In vitro	In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). In vitro tests indicated that peroxidase-like complexes could be formed between Bpy-COOH and Cu(II). It could be concluded that the use of Bpy-COOH could significantly decrease Cu(II) toxicity to algal cells by forming peroxidase-like complexes.[1] Members of a series of 2,2'-bipyridines have been synthesized and tested as inhibitors of prolyl hydroxylase. [2,2'-bipyridine]-5,5'-dicarboxylic acid (IC50 = 0.19 microM) is the most potent inhibitor of its type yet reported.[2]
In vivo	In this study, we evaluated the role of 2,2'-bipyridine-5,5'-dicarboxylic acid (Bpy-COOH) in protecting Chlorella vulgaris from the oxidative stress and toxicity induced by Cu(II). The in vivo experiments showed that the production of reactive oxygen species in C. pyrenoidosa treated by the addition of Bpy-COOH and Cu(II) in three orders were all significantly less than that in cases treated with only Cu(II).[1]
Target activity	Prolyl hydroxylase:0.19 microM
molecular weight	244.2
Molecular formula	C12H8N2O4
CAS	1802-30-8
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 1 mg/mL, Sonication is recommended.
References	1. Wen Y, et al. Protection against Cu(II)-induced oxidative stress and toxicity to Chlorella vulgaris by 2,2'-Bipyridine-5,5'-dicarboxylic acid. Arch Environ Contam Toxicol. 2014;66(3):400-406. 2. Hales NJ, et al. Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives. J Med Chem. 1993;36(24):3853-3858. 3. Wang C, et al. Doping metal-organic frameworks for water oxidation, carbon dioxide reduction, and organic photocatalysis. J Am Chem Soc. 2011;133(34):13445-13454.

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Prolyl-4-hydroxylase Inhibitor 11

CAS No.: 1802-30-8