| Description | Prezalumab (AMG 557) is a human IgG2 monoclonal antibody against ICOSL and BAFF. Prezalumab can be used to study sjogren's syndrome cutaneous lupus erythematosus, psoriasis, systemic lupus erythematosus arthritis and systemic lupus erythematosus (SLE). |
| In vivo | 在小鼠NZB/NZW红斑狼疮模型和胶原诱导性关节炎(CIA)模型中，Prezalumab比单一的ICOSL或BAFF抑制剂显示出更高的效能[1]。与BAFF抑制的药理作用类似，Prezalumab能够减少猕猴体内的B细胞数量[1]。 |
| Synonyms | AMG 557 |
| molecular weight | N/A |
| CAS | 1523164-68-2 |
| Storage | store at low temperature | store at -80°C |
| References | 1. Zhang M, et al. Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914. |