| Description | Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator. |
| Target activity | sGC:（EC50）197 nM |
| Synonyms | IW-1973 |
| molecular weight | 534.36 |
| Molecular formula | C21H14F8N6O2 |
| CAS | 1628730-49-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 245 mg/mL (458.50 mM) |
| References | 1. Daniel P Zimmer, et al. Abstract 16938: IW-1973 is a Potent Soluble Guanylate Cyclase Stimulator in vitro and in vivo With Extensive Tissue Distribution. |