| Description | PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity. |
| In vitro | 相较于其他七种核苷酸激活的 P2Y 受体，PPTN 对 P2Y14-R 具有强烈的选择性。在区分的 HL-60 人类早幼粒细胞白血病细胞中，PPTN 能够在10 μM UDP-葡萄糖存在下以约1 nM 的 IC50 抑制 UDP-葡萄糖促进的趋化性，且在100 μM[1] UDP-葡萄糖存在下约为4 nM。 |
| Target activity | P2Y14 receptor:434 pM (KB) |
| molecular weight | 475.5 |
| Molecular formula | C29H24F3NO2 |
| CAS | 1160271-30-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1.58 mg/ml (3.33 mM), Sonication is recommended. Ethanol: insoluble |
| References | 1. Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. 2. Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567. |