| Description | Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). |
| In vitro | 这两种以及从硬骨质体中分离出的另外八种已知化合物，包括Poricoic acid B (3)、poricoic acid A (4)、tumulosic acid (5)、dehydrotumulosic acid (6)、3-epidehydrotumulosic acid (7)、polyporenic acid C (8)、25-hydroxy-3-epidehydrotumulosic acid (9)以及dehydroabietic acid methyl ester (10)，均显示出对由肿瘤促进剂12-O-十四酰基酞菁-13-酸酯（TPA）诱导的Epstein-Barr病毒早期抗原（EBV-EA）激活有强效的抑制作用。通过评估化合物1和4对人类癌细胞系的细胞毒性，发现1对白血病HL-60细胞显示出显著的细胞毒性[GI(50)值为39.3 nM]，尽管对其他细胞的细胞毒性只是中等水平。化合物4对所有测试的癌细胞系表现出中等的细胞毒性。 |
| Synonyms | 茯苓酸B, 茯苓新酸 B |
| molecular weight | 484.67 |
| Molecular formula | C30H44O5 |
| CAS | 137551-39-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (46.42 mM) |
| References | 1. Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.J Nat Prod. 2002 Apr;65(4):462-5. |