| Description | Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthetic conjugate compound incorporating the cereblon ligand from Pomalidomide and a linker commonly utilized in PROTAC technology. This compound functions as an E3 ligase ligand-linker conjugate in biochemical reactions. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| Synonyms | Pomalidomide-amino-PEG3-NH2 hydrochloride |
| molecular weight | 498.92 |
| Molecular formula | C21H27ClN4O8 |
| CAS | 2380273-75-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. 2. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
Pomalidomide-amino-PEG3-NH2 hydrochloride
CAS No.: 2380273-75-4
Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthetic conjugate compound incorporating the cereblon ligand from Pomal
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