| Description | Pomalidomide-6-OH, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC [1]). |
| In vitro | PROTACs由连接两种不同配体的连接器构成；一个是E3泛素连接酶的配体，另一个是目标蛋白的配体。PROTACs利用细胞内的泛素-蛋白酶体系统，有选择性地降解目标蛋白[1]。 |
| molecular weight | 289.24 |
| Molecular formula | C13H11N3O5 |
| CAS | 1547162-44-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |