| Description | Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry. |
| In vitro | Butanoic acid, 4-[[2-(2,6-二氧化-3-哌啶基)-2,3-二氧化-1H-异吲哚-4-基]氨基]是用于PROTAC®研究与开发的功能化的cereblon配体.它结合了一个E3连接酶配体和带有末端酸基的alkylC3连接器，准备与目标蛋白质配体进行结合。 |
| Synonyms | 4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid |
| molecular weight | 359.33 |
| Molecular formula | C17H17N3O6 |
| CAS | 2225940-47-4 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Liu, Jing; Plewe, Michael Bruno; Wang, Jialiang; Han, Xiaoran; Chen, Liqun. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. |
Pomalidomide 4'-alkylC3-acid
CAS No.: 2225940-47-4
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin
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