| Description | Polzastobart (JTX-8064), a humanized IgG4 monoclonal antibody, functions as an antagonist selectively targeting LILRB2. It inhibits its interaction with both classical and non-classical MHC I molecules. By preventing LILRB2 from binding to HLA-A/B and HLA-G, which are associated with immunotolerance in cancer cells, Polzastobart promotes the production of pro-inflammatory cytokines in macrophages, thereby serving as a macrophage immune checkpoint inhibitor [1]. |
| Synonyms | JTX 8064 |
| molecular weight | N/A |
| CAS | 2640981-19-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years |