| Description | Polygalacturonic acid (Galacturonic acid polymer), a transparent colloid, constitutes a significant portion of the cell wall. It is employed in the synthesis of silver nanoparticles (AgNPs), serving both as an antioxidant and anti-inflammatory agent to shield cells from the harmful impacts of elevated reactive oxygen species (ROS) and to expedite wound healing. Additionally, Polygalacturonic acid nanoparticles exhibit antibacterial properties [1] [2]. |
| In vitro | 聚半乳糖醛酸能够形成耐久的水凝胶，延长药物效果。例如，聚半乳糖醛酸水凝胶/透明质酸与伊布洛芬结合，能预防椎板切除术后成年雄性大鼠硬膜外纤维化，这是一种严重的瘢痕组织粘连，同时提高局部炎症控制的效率，减少伊布洛芬的副作用[1]。聚半乳糖醛酸水凝胶/透明质酸（PGA-HA）（2%，200 μL；24小时）对L929成纤维细胞表现出低细胞性毒[1]。聚半乳糖醛酸（PGA）制备的（Ag-PGA/HA）-PVA纳米粒子，对革兰氏阳性菌株巴斯德杆菌和金黄色葡萄球菌，以及革兰氏阴性菌株大肠杆菌，展现出抗菌活性[2]。 |
| In vivo | 聚半乳糖醛酸（外部用药；14天）可促进白鼠伤口感染的快速愈合[2]。 |
| Synonyms | Galacturonic acid polymer |
| molecular weight | N/A |
| Molecular formula | (C6H10O7)x |
| CAS | 25990-10-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |