| Description | Poly-L-lysine hydrochloride plays a key role in promoting cell attachment to solid substrates by enhancing the electrostatic interaction between the negatively charged ions present on the cell membrane and the surface of the culture substrate as a non-specific attachment factor.Poly-L-lysine hydrochloride is a peptide that at low concentrations Due to its cationic peptide nature, Poly-L-lysine hydrochloride is antimicrobially active. These properties make it an important component for enhancing cell adhesion, regulating phase separation kinetics and demonstrating antimicrobial activity. |
| In vitro | Poly-L-lysine是一种食品级抗菌肽，可与蛋白质形成复合物，这些复合物是潜在的靶向输送载体。采用静电势模型对EPL进行了描述，以揭示其与蛋白质的相互作用亲和力。研究建立了一个三维相界线曲线，将复合过程分为纳米尺度结合和相分离两部分。[2] |
| molecular weight | N/A |
| Molecular formula | (C6H14N2O2.ClH)x |
| CAS | 26124-78-7 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 45.0 mg/mL, Sonication and heating are recommended. |
| References | 1. Archishman Ghosh, et al. Three archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019;116(39):19474-19483. 2. Liang Guo, et al. pH-induced structural transition during complexation and precipitation of sodium caseinate and ε-Poly-l-lysine. Int J Biol Macromol. 2020;154:644-653. 3. Li Z, et al. Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline). J Control Release. 2004;98(3):437-446. |