| Description | Polidocanol (Polyoxyethylene lauryl ether) is an alkyl polyethylene glycol ether of lauryl alcohol, which is a derivative of natural fatty or alkyl alcohols in natural mineral oil and is a hardener. Polidocanol can be used as a local anesthetic, but in combination with other anesthetic drugs there is a risk of enhancing the effects of the anesthetic drugs on the cardiovascular system. |
| In vivo | Polidocanol (0.5%, 1%, and 2%) causes obviously more adhesions than tetracycline, whereas the effect of diluted polidocanol is similar to that of tetracycline in rats. The higher concentrations of polidocanol, of 0.5%, 1%, and 2% are more effective than either the diluted polidocanol or tetracycline against pleurodesis.[1] |
| Synonyms | Polyoxyethylene lauryl ether, Polyoxyethyleneglycol Dodecyl Ether |
| molecular weight | avg. 1198.0 |
| Molecular formula | (C2H4O)nC12H26O |
| CAS | 9002-92-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 45.0 mg/mL, Sonication is recommended. DMSO: 45.0 mg/mL, Sonication is recommended. |
| References | 1. Cetin B, et al. Polidocanol at different concentrations for pleurodesis in rats. Surg Today. 2005;35(12):1066-1069. |