| Description | Pociredir (FTX-6058) is a potent, selective and orally active inhibitor of embryonic ectoderm development (EED) (KD= 0.163 nM). Pociredir (FTX-6058) has research value in inflammatory or hemoglobinopathies, such as sickle cell disease (SCD). |
| In vivo | Pociredir (FTX-6058) (QD, 5 mg/kg) reduces the H3K27me3 levels in the Townes mouse model of sickle cell disease (SCD). Pociredir (FTX-6058) (QD, 5 mg/kg) increases the levels of red blood cells and total hemoglobin, ameliorates hemolysis in the Townes mouse model of sickle cell disease (SCD) [1]. |
| molecular weight | 403.41 |
| Molecular formula | C22H18FN5O2 |
| CAS | 2490674-02-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |