| Description | PNU-142721, reverse transcriptase inhibitor, is used to treat human immunodeficiency virus (HIV) infection. |
| Synonyms | PNU 142721 |
| molecular weight | 306.77 |
| Molecular formula | C13H11ClN4OS |
| CAS | 185220-03-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chen KB, Chen HY, Chen KC, Chen CY. Treatment of cardiovascular disease by traditional Chinese medicine against pregnane X receptor. Biomed Res Int. 2014;2014:950191. doi: 10.1155/2014/950191. Epub 2014 Jun 22. PubMed PMID: 25050380; PubMed Central PMCID: PMC4090537. 2. Pal M, Srivastava G, Moon LS, Jolly RS. Bioreduction of methyl heteroaryl and aryl heteroaryl ketones in high enantiomeric excess with newly isolated fungal strains. Bioresour Technol. 2012 Aug;118:306-14. doi: 10.1016/j.biortech.2012.05.031. Epub 2012 May 17. PubMed PMID: 22705956. 3. Cheng Y, Redinbo MR. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci. 2011 Oct;20(10):1713-9. doi: 10.1002/pro.706. Epub 2011 Sep 12. PubMed PMID: 21805522; PubMed Central PMCID: PMC3218365. 4. Lindberg J, Sigurdsson S, Löwgren S, Andersson HO, Sahlberg C, Noréen R, Fridborg K, Zhang H, Unge T. Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Eur J Biochem. 2002 Mar;269(6):1670-7. PubMed PMID: 11895437. |