| Description | Plecanatide acetate is a agonist of guanylate cyclase-C (GC-C) receptor( EC50 of 190 nM in T84 cells), and shows anti-inflammatory activity in models of murine colitis. |
| In vitro | Plecanatide acetate is a GC-C receptor agonist, binds and activates GC-C receptor(EC50 of 190 nM in T84 cells)[1]. |
| Target activity | GC-C (T84 cells):190 nM (EC50) |
| molecular weight | 1741.94 |
| Molecular formula | C67H108N18O28S4 |
| CAS | 1075732-84-1 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Shailubhai K, et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22. |