| Description | Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced splenocyte proliferation in the OVA-immunized mice. Platycodin D3 also exerts anti-Hepatitis C virus (HCV) activity. |
| In vitro | 本研究旨在评估桔梗（Platycodon grandiflorum, PG）根提取物中含有的三萜皂苷对HCV复制子细胞和细胞培养HCV（HCVcc）感染细胞的病毒酶活性及复制的功能效应。通过NS5B RNA依赖性RNA聚合酶检测，确认了PG中三萜皂苷的抑制活性，并在HCV复制的背景下进一步得到验证。确定了六种三萜皂苷（platycodin D、platycodin D2、Platycodin D3、deapioplatycodin D、deapioplatycodin D2 和 platyconic acid A）及PG皂苷混合物（PGSM）作为具有抗HCV活性的活性成分。值得注意的是，PGSM与干扰素-α或NS5A抑制剂联合使用时，表现出协同的抗HCV活性。 |
| Synonyms | 桔梗皂苷D3, 桔梗皂苷 D3 |
| molecular weight | 1387.46 |
| Molecular formula | C63H102O33 |
| CAS | 67884-03-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (43.24 mM) |
| References | 1. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication.Evid Based Complement Alternat Med. 2013;2013:560417. |
| Citations | 1. Lee S J, Kim H W, Lee S, et al. Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS. Molecules. 2022, 27(1): 107. |