| Description | PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.) |
| In vivo | PKM2 activator 3 (compound 66) has good Caco-2 permeability, a low efflux ratio (0.84) and high microsomal stability (t 1/2 = 277.2 min in human liver microsomes and 117.5 min in mouse liver microsomes) [1]. |
| molecular weight | 372.77 |
| Molecular formula | C15H11ClF2N2O3S |
| CAS | 1346113-84-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |