| Description | Pimozide D4 is a deuterium labeled Pimozide. |
| Target activity | STAT3:, α1-adrenoceptor:39 nM (ki), D2 receptor:1.4 nM (ki), Opamine D1 receptor:588 nM (ki), STAT5:, Opamine D3 receptor:2.5 nM (ki) |
| Synonyms | Pimozide D4, R6238 D4 |
| molecular weight | 465.57 |
| Molecular formula | C28H29F2N3O |
| CAS | 1803193-57-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256(2):141-7. 2. Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017. 3. Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117(12): 3421-3429. |