| Description | PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity. |
| In vitro | PIM1-IN-1 induces apoptosis in SKMEL19 cells[1]. |
| In vivo | PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice[1]. |
| Target activity | Pim1:7 nM, Pim3:70 nM, Pim2:5530 nM |
| molecular weight | 474.56 |
| Molecular formula | C25H30N8O2 |
| CAS | 1417630-95-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Martínez-González S, et al. Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. Eur J Med Chem. 2019 Feb 19;168:87-109. |