| Description | Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. |
| Target activity | LKB1:380 nM (Kd), Pim1:35 nM (Kd), MST2:75 nM (Kd), AKK1:53 nM (Kd) |
| Synonyms | LKB1/AAK1 dual inhibitor, MDK-2275 |
| molecular weight | 339.35 |
| Molecular formula | C20H13N5O |
| CAS | 1093222-27-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 15 mg/mL (44.2 mM) |
| References | 1. Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51(24):7898-914. |
| Citations | 1. Wang T, Guo H, Li Q, et al. The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations. Cell Reports. 2022, 40(8): 111210 2. Yang W, Sun X, Liu S, et al.TLR8 agonist Motolimod-induced inflammatory death for treatment of acute myeloid leukemia.Biomedicine & Pharmacotherapy.2023, 163: 114759. |