| Description | Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim protein kinases. This compound is valuable in cancer research, with a notable application in studying prostate cancer [1]. |
| In vitro | Pim-1/2 kinase inhibitor 1（不同浓度；48小时）对PC3细胞表现出细胞毒性，IC为11μM[1]。细胞毒性测定[1]细胞系：PC3细胞，浓度：不同浓度，孵育时间：48小时，结果：以11μM的IC抑制了PC3细胞。 |
| molecular weight | 235.26 |
| Molecular formula | C11H9NO3S |
| CAS | 6320-51-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (212.53 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1. |