| Description | PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. It also exhibits varying inhibitory effects on other PI3K isoforms, with IC50 values of 4768 nM for PI3Kα, 878.1 nM for PI3Kβ, and 355.2 nM for PI3Kδ. |
| In vivo | PI3Kγ抑制剂7（化合物2）（5 mg/kg；口服）在ICR小鼠中表现出优秀的药代动力学属性，半衰期为3.4小时，生物利用度为60%[1]。通过每日一次口服，连续21天，剂量达到60 mg/kg的PI3Kγ抑制剂7在小鼠模型中展现了显著的抗肿瘤效果[1]。 |
| Target activity | PI3Kα:4768 nM, PI3Kβ:878.1 nM, PI3Kγ:3.42 nM, PI3Kδ:355.2 nM |
| molecular weight | 555.59 |
| Molecular formula | C31H25N9O2 |
| CAS | 2575863-25-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |