| Description | PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function. |
| Target activity | PI3Kβ:1.65 μM, PI3Kδ:9 nM, PI3Kγ:4.63 μM, PI3Kα:0.262 μM |
| Synonyms | TC KHNS 11 |
| molecular weight | 492.53 |
| Molecular formula | C28H24N6O3 |
| CAS | 1431540-99-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (101.52 mM) |
| References | 1. Hoegenauer K, et al. Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2016 Jun 2;7(8):762-7. |