| Description | PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively. This compound also induces apoptosis and is utilized in cancer research [1]. |
| In vitro | 该化合物PI3K/VEGFR2-IN-1（化合物8；1.56-100 µM；24小时；HePG2、MCF-7、Hela和PC3细胞）能剂量依赖性抑制细胞增殖[1]。同一化合物（10 mg/mL；24小时；MCF-7和Hela细胞）可导致细胞周期在G1/S阶段停滞并诱导凋亡[1]。 |
| Target activity | PI3K:2.21 μM, VEGFR2:68 μM |
| molecular weight | 343.83 |
| Molecular formula | C17H14ClN3OS |
| CAS | 2851067-08-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |